enu mouse mutant lines Search Results


enu mouse mutant lines  (BioResource International Inc)
90
BioResource International Inc enu mouse mutant lines
Enu Mouse Mutant Lines, supplied by BioResource International Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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rdh10 enu point mutation mice  (Genentech inc)
90
Genentech inc rdh10 enu point mutation mice
Retinoic acid regulates β-catenin expression in brain endothelial cells. (A) Immunofluorescent images of coronal forebrain sections from E13.5 Wild-type ( <t>Rdh10</t> +/+ or Rdh10 +/- ) and Rdh10 ( Rdh10 -/- ) mutants stained for β-catenin (green), Isolectin-b4 (Ib4; red), and DAPI (blue). Scale bars are 200 μm. (B,C) Immunohistochemical images of (B) thalamic (thal) regions from E13.5 Wild-type ( Rdh10 +/+ or Rdh10 +/- ; inset from A ) and Rdh10 ( Rdh10 -/- ; inset from A ) mutants and (C) cortical plate from E18.5 dnRAR403 fl/fl and Pdgfbi cre/+ ; dnRAR403 fl/fl brains stained for β-catenin (green) and Ib4 (red). Arrows indicate positive β-catenin expression within the Ib4 + vasculature. Scale bars are 50 μm. (B’,C’) Quantification and analyses (Student’s t -test) for percent of β-catenin expression within the total Ib4 + labeled blood vessels from (B’) Wild-type (gray; n = 6 animals) and Rdh10 mutant (black; n = 5 animals) and (C’) dnRAR403 fl/fl (gray; n = 6 animals) and Pdgfbi cre/+ ; dnRAR403 fl/fl (black; n = 5 animals). (D) Immunocytochemistry of β-catenin (green) expression in bEnd.3 cells following 48 h of vehicle, 50 nM RA, 1 μM RARi (AGN-194310), and RA + RARi. Scale bars are 50 μm. (D’) Quantification and analyses (ANOVA with Tukey’s post hoc analysis) on fluorescent intensity of β-catenin expression normalized to total number of DAPI+ bEnd.3 cells per field in vehicle (white), RA (black), RARi (gray), RA+RARi (black and gray) treated cells ( n = 3 independent experiments).
Rdh10 Enu Point Mutation Mice, supplied by Genentech inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rdh10 enu point mutation mice/product/Genentech inc
Average 90 stars, based on 1 article reviews
rdh10 enu point mutation mice - by Bioz Stars, 2026-03
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enu mutant mice (g0)  (Jackson Laboratory)
90
Jackson Laboratory enu mutant mice (g0)
Retinoic acid regulates β-catenin expression in brain endothelial cells. (A) Immunofluorescent images of coronal forebrain sections from E13.5 Wild-type ( <t>Rdh10</t> +/+ or Rdh10 +/- ) and Rdh10 ( Rdh10 -/- ) mutants stained for β-catenin (green), Isolectin-b4 (Ib4; red), and DAPI (blue). Scale bars are 200 μm. (B,C) Immunohistochemical images of (B) thalamic (thal) regions from E13.5 Wild-type ( Rdh10 +/+ or Rdh10 +/- ; inset from A ) and Rdh10 ( Rdh10 -/- ; inset from A ) mutants and (C) cortical plate from E18.5 dnRAR403 fl/fl and Pdgfbi cre/+ ; dnRAR403 fl/fl brains stained for β-catenin (green) and Ib4 (red). Arrows indicate positive β-catenin expression within the Ib4 + vasculature. Scale bars are 50 μm. (B’,C’) Quantification and analyses (Student’s t -test) for percent of β-catenin expression within the total Ib4 + labeled blood vessels from (B’) Wild-type (gray; n = 6 animals) and Rdh10 mutant (black; n = 5 animals) and (C’) dnRAR403 fl/fl (gray; n = 6 animals) and Pdgfbi cre/+ ; dnRAR403 fl/fl (black; n = 5 animals). (D) Immunocytochemistry of β-catenin (green) expression in bEnd.3 cells following 48 h of vehicle, 50 nM RA, 1 μM RARi (AGN-194310), and RA + RARi. Scale bars are 50 μm. (D’) Quantification and analyses (ANOVA with Tukey’s post hoc analysis) on fluorescent intensity of β-catenin expression normalized to total number of DAPI+ bEnd.3 cells per field in vehicle (white), RA (black), RARi (gray), RA+RARi (black and gray) treated cells ( n = 3 independent experiments).
Enu Mutant Mice (G0), supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/enu mutant mice (g0)/product/Jackson Laboratory
Average 90 stars, based on 1 article reviews
enu mutant mice (g0) - by Bioz Stars, 2026-03
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cflip-l 46 mutant mouse lines  (BioResource International Inc)
90
BioResource International Inc cflip-l 46 mutant mouse lines
Retinoic acid regulates β-catenin expression in brain endothelial cells. (A) Immunofluorescent images of coronal forebrain sections from E13.5 Wild-type ( <t>Rdh10</t> +/+ or Rdh10 +/- ) and Rdh10 ( Rdh10 -/- ) mutants stained for β-catenin (green), Isolectin-b4 (Ib4; red), and DAPI (blue). Scale bars are 200 μm. (B,C) Immunohistochemical images of (B) thalamic (thal) regions from E13.5 Wild-type ( Rdh10 +/+ or Rdh10 +/- ; inset from A ) and Rdh10 ( Rdh10 -/- ; inset from A ) mutants and (C) cortical plate from E18.5 dnRAR403 fl/fl and Pdgfbi cre/+ ; dnRAR403 fl/fl brains stained for β-catenin (green) and Ib4 (red). Arrows indicate positive β-catenin expression within the Ib4 + vasculature. Scale bars are 50 μm. (B’,C’) Quantification and analyses (Student’s t -test) for percent of β-catenin expression within the total Ib4 + labeled blood vessels from (B’) Wild-type (gray; n = 6 animals) and Rdh10 mutant (black; n = 5 animals) and (C’) dnRAR403 fl/fl (gray; n = 6 animals) and Pdgfbi cre/+ ; dnRAR403 fl/fl (black; n = 5 animals). (D) Immunocytochemistry of β-catenin (green) expression in bEnd.3 cells following 48 h of vehicle, 50 nM RA, 1 μM RARi (AGN-194310), and RA + RARi. Scale bars are 50 μm. (D’) Quantification and analyses (ANOVA with Tukey’s post hoc analysis) on fluorescent intensity of β-catenin expression normalized to total number of DAPI+ bEnd.3 cells per field in vehicle (white), RA (black), RARi (gray), RA+RARi (black and gray) treated cells ( n = 3 independent experiments).
Cflip L 46 Mutant Mouse Lines, supplied by BioResource International Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cflip-l 46 mutant mouse lines - by Bioz Stars, 2026-03
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mouse mutants  (Jackson Laboratory)
90
Jackson Laboratory mouse mutants
Retinoic acid regulates β-catenin expression in brain endothelial cells. (A) Immunofluorescent images of coronal forebrain sections from E13.5 Wild-type ( <t>Rdh10</t> +/+ or Rdh10 +/- ) and Rdh10 ( Rdh10 -/- ) mutants stained for β-catenin (green), Isolectin-b4 (Ib4; red), and DAPI (blue). Scale bars are 200 μm. (B,C) Immunohistochemical images of (B) thalamic (thal) regions from E13.5 Wild-type ( Rdh10 +/+ or Rdh10 +/- ; inset from A ) and Rdh10 ( Rdh10 -/- ; inset from A ) mutants and (C) cortical plate from E18.5 dnRAR403 fl/fl and Pdgfbi cre/+ ; dnRAR403 fl/fl brains stained for β-catenin (green) and Ib4 (red). Arrows indicate positive β-catenin expression within the Ib4 + vasculature. Scale bars are 50 μm. (B’,C’) Quantification and analyses (Student’s t -test) for percent of β-catenin expression within the total Ib4 + labeled blood vessels from (B’) Wild-type (gray; n = 6 animals) and Rdh10 mutant (black; n = 5 animals) and (C’) dnRAR403 fl/fl (gray; n = 6 animals) and Pdgfbi cre/+ ; dnRAR403 fl/fl (black; n = 5 animals). (D) Immunocytochemistry of β-catenin (green) expression in bEnd.3 cells following 48 h of vehicle, 50 nM RA, 1 μM RARi (AGN-194310), and RA + RARi. Scale bars are 50 μm. (D’) Quantification and analyses (ANOVA with Tukey’s post hoc analysis) on fluorescent intensity of β-catenin expression normalized to total number of DAPI+ bEnd.3 cells per field in vehicle (white), RA (black), RARi (gray), RA+RARi (black and gray) treated cells ( n = 3 independent experiments).
Mouse Mutants, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mouse mutants/product/Jackson Laboratory
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mouse mutants - by Bioz Stars, 2026-03
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enu-induced mutant mice  (UT Battelle)
90
UT Battelle enu-induced mutant mice
Retinoic acid regulates β-catenin expression in brain endothelial cells. (A) Immunofluorescent images of coronal forebrain sections from E13.5 Wild-type ( <t>Rdh10</t> +/+ or Rdh10 +/- ) and Rdh10 ( Rdh10 -/- ) mutants stained for β-catenin (green), Isolectin-b4 (Ib4; red), and DAPI (blue). Scale bars are 200 μm. (B,C) Immunohistochemical images of (B) thalamic (thal) regions from E13.5 Wild-type ( Rdh10 +/+ or Rdh10 +/- ; inset from A ) and Rdh10 ( Rdh10 -/- ; inset from A ) mutants and (C) cortical plate from E18.5 dnRAR403 fl/fl and Pdgfbi cre/+ ; dnRAR403 fl/fl brains stained for β-catenin (green) and Ib4 (red). Arrows indicate positive β-catenin expression within the Ib4 + vasculature. Scale bars are 50 μm. (B’,C’) Quantification and analyses (Student’s t -test) for percent of β-catenin expression within the total Ib4 + labeled blood vessels from (B’) Wild-type (gray; n = 6 animals) and Rdh10 mutant (black; n = 5 animals) and (C’) dnRAR403 fl/fl (gray; n = 6 animals) and Pdgfbi cre/+ ; dnRAR403 fl/fl (black; n = 5 animals). (D) Immunocytochemistry of β-catenin (green) expression in bEnd.3 cells following 48 h of vehicle, 50 nM RA, 1 μM RARi (AGN-194310), and RA + RARi. Scale bars are 50 μm. (D’) Quantification and analyses (ANOVA with Tukey’s post hoc analysis) on fluorescent intensity of β-catenin expression normalized to total number of DAPI+ bEnd.3 cells per field in vehicle (white), RA (black), RARi (gray), RA+RARi (black and gray) treated cells ( n = 3 independent experiments).
Enu Induced Mutant Mice, supplied by UT Battelle, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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c57bl6/j-mpl mice  (Charles River Laboratories)
90
Charles River Laboratories c57bl6/j-mpl mice
Retinoic acid regulates β-catenin expression in brain endothelial cells. (A) Immunofluorescent images of coronal forebrain sections from E13.5 Wild-type ( <t>Rdh10</t> +/+ or Rdh10 +/- ) and Rdh10 ( Rdh10 -/- ) mutants stained for β-catenin (green), Isolectin-b4 (Ib4; red), and DAPI (blue). Scale bars are 200 μm. (B,C) Immunohistochemical images of (B) thalamic (thal) regions from E13.5 Wild-type ( Rdh10 +/+ or Rdh10 +/- ; inset from A ) and Rdh10 ( Rdh10 -/- ; inset from A ) mutants and (C) cortical plate from E18.5 dnRAR403 fl/fl and Pdgfbi cre/+ ; dnRAR403 fl/fl brains stained for β-catenin (green) and Ib4 (red). Arrows indicate positive β-catenin expression within the Ib4 + vasculature. Scale bars are 50 μm. (B’,C’) Quantification and analyses (Student’s t -test) for percent of β-catenin expression within the total Ib4 + labeled blood vessels from (B’) Wild-type (gray; n = 6 animals) and Rdh10 mutant (black; n = 5 animals) and (C’) dnRAR403 fl/fl (gray; n = 6 animals) and Pdgfbi cre/+ ; dnRAR403 fl/fl (black; n = 5 animals). (D) Immunocytochemistry of β-catenin (green) expression in bEnd.3 cells following 48 h of vehicle, 50 nM RA, 1 μM RARi (AGN-194310), and RA + RARi. Scale bars are 50 μm. (D’) Quantification and analyses (ANOVA with Tukey’s post hoc analysis) on fluorescent intensity of β-catenin expression normalized to total number of DAPI+ bEnd.3 cells per field in vehicle (white), RA (black), RARi (gray), RA+RARi (black and gray) treated cells ( n = 3 independent experiments).
C57bl6/J Mpl Mice, supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Retinoic acid regulates β-catenin expression in brain endothelial cells. (A) Immunofluorescent images of coronal forebrain sections from E13.5 Wild-type ( Rdh10 +/+ or Rdh10 +/- ) and Rdh10 ( Rdh10 -/- ) mutants stained for β-catenin (green), Isolectin-b4 (Ib4; red), and DAPI (blue). Scale bars are 200 μm. (B,C) Immunohistochemical images of (B) thalamic (thal) regions from E13.5 Wild-type ( Rdh10 +/+ or Rdh10 +/- ; inset from A ) and Rdh10 ( Rdh10 -/- ; inset from A ) mutants and (C) cortical plate from E18.5 dnRAR403 fl/fl and Pdgfbi cre/+ ; dnRAR403 fl/fl brains stained for β-catenin (green) and Ib4 (red). Arrows indicate positive β-catenin expression within the Ib4 + vasculature. Scale bars are 50 μm. (B’,C’) Quantification and analyses (Student’s t -test) for percent of β-catenin expression within the total Ib4 + labeled blood vessels from (B’) Wild-type (gray; n = 6 animals) and Rdh10 mutant (black; n = 5 animals) and (C’) dnRAR403 fl/fl (gray; n = 6 animals) and Pdgfbi cre/+ ; dnRAR403 fl/fl (black; n = 5 animals). (D) Immunocytochemistry of β-catenin (green) expression in bEnd.3 cells following 48 h of vehicle, 50 nM RA, 1 μM RARi (AGN-194310), and RA + RARi. Scale bars are 50 μm. (D’) Quantification and analyses (ANOVA with Tukey’s post hoc analysis) on fluorescent intensity of β-catenin expression normalized to total number of DAPI+ bEnd.3 cells per field in vehicle (white), RA (black), RARi (gray), RA+RARi (black and gray) treated cells ( n = 3 independent experiments).

Journal: Frontiers in Cellular Neuroscience

Article Title: Retinoic Acid Regulates Endothelial β-catenin Expression and Pericyte Numbers in the Developing Brain Vasculature

doi: 10.3389/fncel.2018.00476

Figure Lengend Snippet: Retinoic acid regulates β-catenin expression in brain endothelial cells. (A) Immunofluorescent images of coronal forebrain sections from E13.5 Wild-type ( Rdh10 +/+ or Rdh10 +/- ) and Rdh10 ( Rdh10 -/- ) mutants stained for β-catenin (green), Isolectin-b4 (Ib4; red), and DAPI (blue). Scale bars are 200 μm. (B,C) Immunohistochemical images of (B) thalamic (thal) regions from E13.5 Wild-type ( Rdh10 +/+ or Rdh10 +/- ; inset from A ) and Rdh10 ( Rdh10 -/- ; inset from A ) mutants and (C) cortical plate from E18.5 dnRAR403 fl/fl and Pdgfbi cre/+ ; dnRAR403 fl/fl brains stained for β-catenin (green) and Ib4 (red). Arrows indicate positive β-catenin expression within the Ib4 + vasculature. Scale bars are 50 μm. (B’,C’) Quantification and analyses (Student’s t -test) for percent of β-catenin expression within the total Ib4 + labeled blood vessels from (B’) Wild-type (gray; n = 6 animals) and Rdh10 mutant (black; n = 5 animals) and (C’) dnRAR403 fl/fl (gray; n = 6 animals) and Pdgfbi cre/+ ; dnRAR403 fl/fl (black; n = 5 animals). (D) Immunocytochemistry of β-catenin (green) expression in bEnd.3 cells following 48 h of vehicle, 50 nM RA, 1 μM RARi (AGN-194310), and RA + RARi. Scale bars are 50 μm. (D’) Quantification and analyses (ANOVA with Tukey’s post hoc analysis) on fluorescent intensity of β-catenin expression normalized to total number of DAPI+ bEnd.3 cells per field in vehicle (white), RA (black), RARi (gray), RA+RARi (black and gray) treated cells ( n = 3 independent experiments).

Article Snippet: The Rdh10 ENU point mutation mice were obtained from Andy Peterson at Genentech ( ).

Techniques: Expressing, Staining, Immunohistochemical staining, Labeling, Mutagenesis, Immunocytochemistry

Ectopic vascular WNT signaling in RA mutants result in increased pericytes along the developing brain vasculature. (A–C) Immunohistochemical (IHC) images of the (A) thalamic regions from E13.5 Wild-type ( Rdh10 +/+ or Rdh10 +/- ) and Rdh10 ( Rdh10 -/- ), (B) cortical plate from E18.5 dnRAR403 fl/fl and Pdgfbi cre/+ ; dnRAR403 fl/fl , and (C) cortical plate from E14.5 Ctnnb1 GOF/+ and Pdgfbi cre/+ ; Ctnnb1 GOF/+ brains stained for Pdgfrβ (green) and Isolectin-b4 (Ib4; blue). Enlarged images and arrows indicate Pdgfrβ + pericytes surrounding the Ib4 + vasculature. (A–C’) Quantification and analyses (Student’s t -test) for the number of pericytes co-labeled for Pdgfrβ and CoupTFII (staining not shown)/100 μm of Ib4 + blood vessels from (A’) W ild-type (gray; n = 5 animals) and Rdh10 mutants (black; n = 5 animals), (B’) dnRAR403 fl/fl (gray; n = 6 animals) and Pdgfbi cre/+ ; dnRAR403 fl/fl (black; n = 6 animals), and (C’) Ctnnb1 GOF/+ (gray; n = 4 animals) and Pdgfbi cre/+ ; Ctnnb1 GOF/+ (black; n = 4 animals). Scale bars are 50 μm.

Journal: Frontiers in Cellular Neuroscience

Article Title: Retinoic Acid Regulates Endothelial β-catenin Expression and Pericyte Numbers in the Developing Brain Vasculature

doi: 10.3389/fncel.2018.00476

Figure Lengend Snippet: Ectopic vascular WNT signaling in RA mutants result in increased pericytes along the developing brain vasculature. (A–C) Immunohistochemical (IHC) images of the (A) thalamic regions from E13.5 Wild-type ( Rdh10 +/+ or Rdh10 +/- ) and Rdh10 ( Rdh10 -/- ), (B) cortical plate from E18.5 dnRAR403 fl/fl and Pdgfbi cre/+ ; dnRAR403 fl/fl , and (C) cortical plate from E14.5 Ctnnb1 GOF/+ and Pdgfbi cre/+ ; Ctnnb1 GOF/+ brains stained for Pdgfrβ (green) and Isolectin-b4 (Ib4; blue). Enlarged images and arrows indicate Pdgfrβ + pericytes surrounding the Ib4 + vasculature. (A–C’) Quantification and analyses (Student’s t -test) for the number of pericytes co-labeled for Pdgfrβ and CoupTFII (staining not shown)/100 μm of Ib4 + blood vessels from (A’) W ild-type (gray; n = 5 animals) and Rdh10 mutants (black; n = 5 animals), (B’) dnRAR403 fl/fl (gray; n = 6 animals) and Pdgfbi cre/+ ; dnRAR403 fl/fl (black; n = 6 animals), and (C’) Ctnnb1 GOF/+ (gray; n = 4 animals) and Pdgfbi cre/+ ; Ctnnb1 GOF/+ (black; n = 4 animals). Scale bars are 50 μm.

Article Snippet: The Rdh10 ENU point mutation mice were obtained from Andy Peterson at Genentech ( ).

Techniques: Immunohistochemical staining, Staining, Labeling